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Serotonin Release in Premotor and Motor PD

Parkinson's Disease Study Using Brain Scans

Recruiting
25-85 years
All
Phase N/A
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study investigates Parkinson's disease by using brain imaging techniques to find a biomarker, which is an indicator of the disease's presence and progression. Participants will be involved in the study for 3 months. During this time, the study will use imaging scans like Positron Emission Tomography (PET), Single Photon Emission Computed Tomography (SPECT), and Magnetic Resonance Imaging (MRI) to understand changes in the brain related to Parkinson's disease.

Participants will attend several visits where they will undergo different procedures. These include taking blood samples, having PET scans with a special tracer, and having an MRI scan. A SPECT scan is also part of the study. One optional visit involves a lumbar puncture. Each visit is expected to last around 6 hours.

  • Who can participate: Adults aged 25 to 85 who can understand the study and agree to join. Participants must not be taking drugs that affect serotonin and must not have certain medical conditions or recent drug or alcohol abuse.
  • Study details: Participants will give blood samples and attend all visits. They must follow study rules. The study includes several imaging tests and an optional lumbar puncture.
  • Study timelines and visits: The study will last 3 months. The study requires 5 visits.
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Study details
    Parkinson Disease
    Parkinson's
    Parkinson's Disease
    Neurodegenerative Diseases
    Neurodegeneration
    Positron Emission Tomography

NCT05516732

University of Exeter

17 April 2026

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