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Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of KarXT in Subjects With Psychosis Associated With Alzheimer's Disease (ADEPT-3)

Join a study to test KarXT's safety for Alzheimer's-related psychosis.

Recruiting
55-90 years
All
Phase 3

This study looks at the long-term use of a drug called KarXT for people with Alzheimer's disease who also have psychosis, which means seeing or hearing things that aren't there. It's called an Open-Label Extension Study, meaning everyone knows what medicine they're taking. The study is for people who already finished certain earlier studies (CN012-0026, CN012-0027, or CN012-0056). This study lasts for a year (52 weeks) and the main goal is to see if KarXT is safe and how well people can tolerate it over a long time.

  • The study lasts 52 weeks, so participants should be ready for a year-long commitment.
  • Participants must have stable living conditions and may need approval if moving to a nursing home.
  • Participants cannot join if they have other significant medical issues or are in another study.
Study details
    Psychosis Associated With Alzheimer's Disease

NCT05980949

Karuna Therapeutics, Inc., a Bristol Myers Squibb company

11 October 2026

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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