Severe Aplastic Anemia (SAA) is when the body doesn't make enough new blood cells. It can be treated with immune suppressive therapy (IST) or a bone marrow transplant (BMT). This study compares these treatments in kids and young adults without a family donor. The study will see which treatment helps patients live longer without their disease coming back or getting worse. It will also check how these treatments affect quality of life and fertility and look at certain genes related to SAA.
Participants will be randomly assigned to IST or unrelated donor BMT. This study does not use experimental drugs. The treatments are standard for SAA. Participants will be involved for up to 2 years, with a follow-up between 3 and 5 years.
- Duration: Participation lasts up to 2 years, with a follow-up between 3 and 5 years.
- Treatments: Participants receive standard therapies, not experimental drugs.
- Eligibility: Open to individuals under 25 years with SAA and no family donor.
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