This study is for people with cystic fibrosis (CF) who do not use CF transmembrane conductance regulator (CFTR) modulators. CF is a genetic disorder that affects the lungs and other organs. CFTR modulators are medications that help some people with CF, but not everyone can use them. The REACH study aims to collect health data and samples from these individuals to help develop new treatments and improve research for those who can't use CFTR modulators.

Participation involves regular visits and data collection over 12 months. You must be at least 12 years old and not pregnant. You should not have used CFTR modulators or participated in other drug trials recently.

• The study lasts for 12 months, requiring regular visits.
• Participants must be willing to follow study procedures and visit schedules.
• Eligibility includes not using CFTR modulators or investigational drugs recently.