**Study Overview:** This research aims to examine the effects of a new drug called **BMS-986470** on healthy people and those with **Sickle Cell Disease (SCD)**. SCD is a genetic condition where red blood cells become misshapen, causing pain and other health issues. The study will look at how safe the drug is, how it behaves in the body, and its initial effectiveness. **Cohort Details:** - **Cohort A:** Includes healthy men and women not able to have children. They must have a healthy body weight and no significant health problems. - **Cohort B:** Includes people with SCD having specific blood traits. Participants need to have experienced a certain number of painful crises called vaso-occlusive crises (VOCs) in the past year. **Key Points:** - **Duration & Visits:** The study involves multiple visits, but specific timing isn't detailed here. - **Compensation:** Information on compensation is not provided in the summary. - **Risks:** Participants should not have any major surgeries recently or any serious health problems that could worsen with the study. **Eligibility:** Specific health criteria must be met, including certain blood levels and overall health status. Some participants with recent severe health episodes are not eligible.