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A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations

Investigating Safety of Medication in Cancer with BRAF Changes

Recruiting
10 years and older
All
Phase 2

This study investigates cancer with BRAF alterations. It focuses on participants with either solid tumors or primary central nervous system (CNS) tumors that have specific changes in the BRAF gene.

The study evaluates how safe and effective the investigational medication is for these cancer conditions. It examines the overall impact on health and any potential side effects.

  • Who can participate: Participants must be 10 years or older, weigh at least 30 kg, and have a diagnosis of a solid tumor or CNS tumor with BRAF alterations after prior standard therapies.
  • Study details: Participants will take the investigational medication and may also receive a placebo, an inactive substance that looks like the investigational medicine but does not contain any medicine.
Study details
    Cancer Harboring BRAF Alterations
    HGG
    LGG
    Solid Tumors
    Melanoma BRAF V600E/K Mutated
    Thyroid Cancer

NCT05503797

Fore Biotherapeutics

17 April 2026

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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