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A Global Phase III Study of Rilvegostomig or Pembrolizumab Monotherapy for First-Line Treatment of PD-L1-high Metastatic Non-small Cell Lung Cancer

Trial comparing Rilvegostomig and Pembrolizumab for certain lung cancer patients.

Recruiting
18 years and older
All
Phase 3

This study aims to compare the effectiveness and safety of two medicines, **rilvegostomig** and **pembrolizumab**. These are treatments for a type of lung cancer called **metastatic non-small cell lung cancer (mNSCLC)**. Metastatic means the cancer has spread beyond the lungs. The study is for adults whose cancer cells show a protein called **PD-L1**. **PD-L1** helps some cancers hide from the immune system. The trial is **Phase III**, which means it's quite advanced and involves many people. It's also **double-blind**, meaning neither the doctors nor the participants know who is getting which treatment. This helps ensure fairness and accuracy.

  • **Study Length and Visits:** Participants will need to visit the study site regularly, but the exact schedule will be shared by the research team.
  • **Risks:** Possible side effects or risks will be explained before participation.
  • **Eligibility and Compensation:** Participants must meet specific health criteria, and details on any compensation will be provided by the study coordinators.

Discuss with your doctor if this study fits your needs, and ensure you understand all the details before joining.

Study details
    Carcinoma
    Non-Small Cell Lung

NCT06868277

AstraZeneca

11 October 2026

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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