TRITON-CM Study is a research project to understand how well a medicine called **nucresiran** works for people with a heart condition called transthyretin amyloidosis with cardiomyopathy. This condition happens when abnormal proteins build up in the heart, making it hard for the heart to work properly. The study compares the effects of nucresiran with a placebo, which is a substance that looks like the medicine but has no active ingredients. Researchers want to see if nucresiran can lower the number of deaths and heart-related problems, and improve how patients feel about their health and quality of life. Some people can join the study if they have been diagnosed with this heart condition, have a history of heart failure, and meet other specific health criteria. However, people with very severe heart failure or certain other health issues cannot participate. Key Points:

• The study involves taking either nucresiran or a placebo as part of the trial.
• Participants may need to attend regular health check-ups and tests.
• It's important to discuss with your doctor to understand any potential risks or benefits.