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Minimal Residual Disease Testing for the Early Detection of Cancer Recurrence in Resectable Stage II-IV Colorectal Cancer Patients

Testing for early cancer return in certain colorectal cancer patients.

Recruiting
18 years and older
All
Phase N/A

This study is about two blood tests, Haystack and Signatera, used to find out if colorectal cancer (CRC) comes back after surgery. These tests look for minimal residual disease (MRD), which means tiny amounts of cancer that might be left after treatment. Haystack might be better at finding cancer early compared to Signatera. It's important to find cancer early to have a better chance of curing it.

What's involved in the study?

  • The study will last up to 5 years, with regular blood tests done after surgery.
  • Testing is done before surgery and then frequently during the first 2 years, then every 6 months up to 5 years.
  • Participants must agree to give blood samples and allow access to tissue samples.

To join, you must be 18 or older, have stage II-IV CRC, and have had or plan to have surgery to remove the cancer. You also need to agree to frequent blood tests. You can't join if you can't safely give blood samples or have cancer that can't be removed.

Study details
    Resectable Colorectal Carcinoma
    Stage II Colorectal Cancer AJCC v8
    Stage III Colorectal Cancer AJCC v8
    Stage IV Colorectal Cancer AJCC v8

NCT07125729

City of Hope Medical Center

17 October 2026

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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