This study looks at whether a medicine called *triptorelin* can help protect the ovaries of young females with cancer during chemotherapy. Chemotherapy can sometimes hurt the ovaries, making it hard or impossible to have children later. Triptorelin works by stopping certain hormones temporarily, giving the ovaries a rest during treatment. In this study, some patients will get triptorelin, while others will not, to see if it makes a difference. **Key points:** - The study involves getting triptorelin shots up to 14 days before or within 7 days of starting chemotherapy, lasting around 24 weeks. - Participants will have their blood tested throughout the study and will be followed up 1 and 2 years after treatment. - Eligibility includes being a female under 40, newly diagnosed with cancer (excluding breast cancer), and planning to use certain chemotherapy drugs. This study can help understand if triptorelin effectively prevents ovarian damage during cancer treatment, offering hope for future fertility.