The **ARTIST study** is comparing two ways to treat aortic regurgitation (AR), a condition where blood flows backward in the heart. The study is testing a new device called the **Trilogy™ Transcatheter Heart Valve (THV)** against the traditional surgical method called **Surgical Aortic Valve Replacement (SAVR)**. The goal is to see if the Trilogy THV is just as good as SAVR for people with serious AR. **Key Points:** - **Study Visits:** Participants must agree to attend all follow-up visits after the procedure. - **Eligibility:** Must need heart valve replacement due to AR and be able to use both Trilogy THV and SAVR. - **Risks:** You cannot join if you have severe health conditions, refuse surgery or blood transfusion, or have certain heart structures. Before participating, make sure you meet all criteria and are comfortable with the follow-up visits. Discuss with your doctor to determine if this trial is right for you.