Mechanical thrombectomy (MT) is a procedure to remove blood clots from the brain. The study explores the safety and effectiveness of using the ANA funnel catheter during MT for people with acute ischemic stroke (AIS), caused by a blocked large blood vessel. This device helps guide other tools and stops blood flow temporarily to make the procedure more effective. The study will compare the ANA to standard methods with other tools called stent retrievers, which are devices used to grab and remove clots.

Participants must be between 22-85 years old and have stroke symptoms. They will be treated within 16 hours of symptoms starting. The study will assess the procedure's success and safety by looking at how well blood flow returns and if there are any complications like symptomatic intracranial hemorrhage (sICH), which is bleeding in the brain.

• The study involves comparing two different methods of clot removal during a stroke.
• Participants will be monitored closely for 90 days after the procedure.
• This study may offer a new way to improve stroke treatment.