Necrotizing Soft Tissue Infections (NSTIs) are serious infections that can quickly become dangerous, leading to organ failure or even death. This study aims to improve how we detect NSTIs using a special dye called **Indocyanine Green (ICG)**. ICG is a safe dye approved by the FDA that helps doctors see blood flow in tissues. When injected, it lights up under a special camera, showing if blood vessels are blocked, which is common in NSTIs. This study involves taking pictures of the dye in action at eight medical centers to check its accuracy in diagnosing NSTIs.

**Key Points:**

• Study is observational, meaning it doesn’t change your current treatment.
• You need to be 18 or older and suspected of having NSTIs to participate.
• Pregnant/nursing women or those allergic to ICG cannot join.

By using this imaging method, doctors hope to catch NSTIs earlier, helping improve patient outcomes and survival rates. This study will compare the new method to current tests to find the best way to diagnose NSTIs.