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A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer

Testing new drugs for specific lung cancer mutations.

Recruiting
18 years and older
All
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is looking at how well a new treatment combination works for adults with a specific type of lung cancer called KRAS G12C-mutated, advanced or metastatic non-squamous non-small cell lung cancer (NSCLC). "KRAS G12C" is a specific change in the cancer cells. The study compares two treatments: one with divarasib and pembrolizumab and the other with pembrolizumab, pemetrexed, and either carboplatin or cisplatin. The study checks if these treatments help stop the cancer from growing and if they are safe.

  • To join, participants shouldn't have had previous treatments for this cancer.
  • Participants must be able to receive chemotherapy involving platinum-based drugs.
  • The study involves regular health checks and monitoring.
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Study details
    Non-Small Cell Lung Cancer
    KRAS G12C Lung Cancer

NCT06793215

Hoffmann-La Roche

11 October 2026

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