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A Clinical Study of MK-2214 in People With Early Alzheimer's Disease (MK-2214-004)

Exploring MK-2214 for early Alzheimer's through clinical study.

Recruiting
50-85 years
All
Phase 2
This study is about a treatment called MK-2214 for early Alzheimer's Disease (AD), which affects memory, speech, and decision-making. Researchers want to see if MK-2214 can slow the spread of a protein called tau in the brain, which harms brain cells in AD. A placebo will be used to compare results; it looks like MK-2214 but has no active ingredients. Participants need to have mild memory issues due to AD and a study partner. They should not have had a stroke, certain brain diseases, seizures, or recent serious illnesses. They should be able to have brain scans like CT, PET, or MRI. People living in nursing homes or needing constant care are not eligible.
  • Participants will undergo visits and tests to monitor their brain activity and health.
  • Researchers will check if participants can tolerate MK-2214 safely.
  • Participants must have stable medication for any existing AD therapy for 3 months before joining.
Study details
    Early Alzheimer's Disease

NCT07033494

Merck Sharp & Dohme LLC

17 October 2026

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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