Diabetic Foot Ulcers (DFUs) are open sores on the feet common in people with diabetes. This study aims to find special markers, called biomarkers, which can predict which DFUs are likely to heal. This will help doctors make better treatment decisions.

The study does not involve any new treatments or medicines. Instead, it collects samples like blood and wound fluid to help research. Participants will visit clinics regularly, every other week for the first month, and then monthly for about a year, until their wound heals or for a total of 52 weeks. If the wound heals early, they will have a few more check-ups, including some by phone or video.

• Length: The study lasts up to 78 weeks.
• Participant requirements: Must be 18 or older with diabetes and an open foot ulcer.
• Visits: Regular clinic visits and some follow-ups by phone or video.

Eligible participants should not have gangrene, be on radiation/chemotherapy, or have severe blood flow issues in their legs. This study's results will help improve care for people with DFUs.