**Study Overview:** This study is comparing two medicines, Deucravacitinib and Ustekinumab, to see which is safer for people who have a skin condition called psoriasis. Psoriasis is when your skin gets red, flaky, and itchy. The study is looking at how safe these medicines are when used for a long time.
**Eligibility:** To join, you need to have moderate-to-severe plaque psoriasis. You should also have some heart health risks like high blood pressure, high cholesterol, diabetes, or be a smoker. You cannot join if you've had a recent heart attack, stroke, or cancer in the last five years.
**Key Points:**
- **Length of Study:** The study will monitor participants over a long period to check safety.
- **Visits Needed:** Participants will need to visit the study site regularly for check-ups.
- **Risks:** Those with serious heart conditions or recent cancer history should not participate.
**Note:** This is a safety study, so your health will be closely watched to ensure the medicines are okay for you.
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