This study is to check how well a cream called delgocitinib works for people with a skin condition called palmoplantar pustulosis (PPP). PPP is a disease with pus-filled bumps on the hands and feet. The study will last about 18 weeks and includes 9 visits to the doctor.

Participants need to be adults with mild to severe PPP and should not have any other severe skin issues. They must not have recent infections or be pregnant. Participants should not have used certain medications or treatments like strong creams, light therapy, or biologic drugs before joining this study.

• The study lasts for about 18 weeks, requiring 9 visits to the clinic.
• Participants must be 18 years or older with mild to severe PPP.
• Some past treatments or recent infections might make you ineligible.