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Immunotherapy (Toripalimab) for Reducing Recurrence Risk After Surgery for Mismatch Repair Deficient Stage IIB, IIC, or III Colon Cancer

Testing Toripalimab to prevent colon cancer return after surgery.

Recruiting
18 years and older
All
Phase 2

Immunotherapy Study for Colon Cancer: This study is about using a medicine called toripalimab to help stop colon cancer from coming back after surgery. This medicine is a type of treatment called immunotherapy, which helps your body's own immune system fight cancer. The study is for people who have a specific type of colon cancer called mismatch repair deficient (dMMR) cancer, which means their cancer cells have trouble fixing mistakes in their DNA.

Participants in this study will receive toripalimab through an IV (a tube that goes into a vein) every 3 weeks for 6 months. After the treatment, doctors will check on the participants every 6 months for up to 5 years. They will use blood tests and scans to see if the cancer comes back and will ask about how the participants feel through surveys.

  • Duration: 6 months of treatment, with follow-ups for up to 5 years.
  • Visits: IV infusions every 3 weeks and regular check-ups post-treatment.
  • Participation: Participants must meet specific health criteria and agree to the study terms.
Study details
    Localized Colon Carcinoma
    Stage IIB Colon Cancer AJCC v8
    Stage IIC Colon Cancer AJCC v8
    Stage III Colon Cancer AJCC v8

NCT07140679

Emory University

17 October 2026

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