Orforglipron is being tested to see if it's safe and works well for women who have stress urinary incontinence (SUI) and are overweight or have obesity. SUI means that you might leak urine when you cough, exercise, or move. This study will last about 58 weeks, which is a little more than a year, including check-ups for safety.

• Participation lasts about 58 weeks, including safety follow-up.
• You should not have had urinary surgery or recent Botox for bladder issues.
• If you're pregnant or recently had a baby, you can't join this study.

To join, you must have a body mass index (BMI) of 27 or more and have SUI. You can't join if you've recently lost a lot of weight, used certain weight loss medicines, or if you have diabetes. Pregnant women or those planning to be pregnant or breastfeeding can't participate. The study checks if you’re healthy enough and don't have conditions like heart issues or diabetes.