This study looks at the safety and effectiveness of **orforglipron**, a medication, in people who are overweight or have obesity, and also have knee **osteoarthritis (OA)**, a condition causing pain and stiffness in the knee. The study will last about 74 weeks, which is a little over a year. To join, participants need to have a **Body Mass Index (BMI)** of 27 or higher, have tried unsuccessfully to lose weight before, and have knee OA. They must be over 50, have morning knee stiffness, or hear a crackling sound in their knee. Participants should not have gained or lost more than 11 pounds recently, have had obesity surgery, have a knee infection, or have diabetes. Additionally, those with recent heart issues or who have used a specific type of medication in the past six months cannot join.

• The study duration is about 74 weeks.
• Participants must have knee pain and be overweight or obese.
• Some health conditions and recent surgeries can exclude you from participating.