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Radiation Therapy (RT) for Parkinson's Disease (PD)

Radiation Therapy (RT) for Parkinson's Disease (PD)

Enrolling By Invitation
45-70 years
All
Phase N/A

Overview

The purpose of this study is to investigate the use of ultra-low, anti-inflammatory doses of radiation therapy (RT) for the treatment of Parkinson's Disease (PD). In this study, the TrueBeam LINAC utilizes a linear accelerator (LINAC) for the delivery of radiation therapy. Dynamic conformal arc (DCA) therapy will be used to deliver a total of five (5) once-a-day radiation treatments (RT) using DaT-SPECT (Dopamine Transporter-Single-Photon Emission Computed Tomography) and MRI imaging to guide radiation treatment planning.

Eligibility

Inclusion Criteria

  • Age ≥ 45 and ≤ 70 years
  • Diagnosis of Parkinson's disease by a Movement Disorder Neurologist
  • Confirmation of unilateral Parkinson's disease by Dopamine Transporter (DaT) scan
  • A score of 2 or less on the modified Hoehn and Yahr scale
  • ECOG Performance Status (PS) ≤ 2 (Appendix I).
  • No known genetic causes or predisposition to Parkinson's disease or related diseases.
  • Ability to complete questionnaires, neurological exam, and follow-up imaging independently or with assistance
  • Ability to provide written informed consent
  • Willing to provide mandatory blood samples for correlative research purposes
  • Willing to return to enrolling institution for follow-up

Exclusion Criteria

  • Concomitant dementia diagnosis or concerns of other memory disorder
  • Parkinson's Disease medication changes within the last 3 months
  • Receipt of radiation therapy for Parkinson's Disease outside Mayo Clinic, Rochester

Print
Study details
    Parkinson's Disease

NCT07218952

Mayo Clinic

20 June 2026

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