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Early Use of Tacrolimus in HLA-Mismatched Haploidentical Allogeneic Hematopoietic Transplantation With Post-Transplant Cyclophosphamide

Testing early Tacrolimus in specific stem cell transplants.

Recruiting
18-80 years
All
Phase 2

This study looks at using a medicine called Tacrolimus early in a type of transplant to see if it makes the process safer. The transplant is called hematopoietic stem cell transplantation, where new cells are put in your body to make healthy blood. Sometimes, the body can react badly, causing a problem called Cytokine Release Syndrome (CRS). Researchers want to find out if starting an immune system calming medicine early can help reduce CRS.

  • Length of Study: Participation involves multiple visits for treatment and follow-ups.
  • Eligibility: Only patients with specific conditions and a matching donor can join.
  • Risks and Benefits: There are potential risks like side effects, but the study aims to improve transplant safety.

To join, a person must have a specific type of blood cancer and a matching donor. They cannot join if they have serious health issues or are pregnant. This study is important because it may help make transplants safer for people in the future.

Study details
    Hematologic Disease and Disorders
    Hematopoietic Cell Transplant

NCT06828796

Northside Hospital, Inc.

17 October 2026

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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