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Efficacy & Safety of Olvi-Vec and Platinum-doublet + Bevacizumab Compared to Physician's Choice of Chemotherapy and Bevacizumab in Platinum-Resistant/Refractory Ovarian Cancer (PRROC) (OnPrime, GOG-3076)

Trial comparing Olvi-Vec treatment with standard chemotherapy for ovarian cancer.

Recruiting
18 years and older
Female
Phase 3

This study tests a new treatment for women with platinum-resistant/refractory ovarian cancer, which means their cancer does not respond well to traditional platinum-based chemotherapy. The study compares two groups: one gets an experimental treatment called Olvi-Vec (a virus-based therapy that helps the immune system fight cancer), followed by standard chemotherapy and a drug called bevacizumab, which helps prevent the growth of new blood vessels in tumors. The other group receives the doctor's choice of chemotherapy and bevacizumab.

  • Participants will need at least 3 prior treatments and must not have certain types of infections or other health issues.
  • The study involves a single cycle of Olvi-Vec administered over two consecutive days, followed by chemotherapy.
  • Participants may need to provide biological samples for testing, and regular monitoring is required.

This study aims to find out if the new treatment can make tumors more sensitive to chemotherapy and improve survival outcomes. Participants should discuss potential risks and benefits with their doctor before joining.

Study details
    Platinum-resistant Ovarian Cancer
    Platinum-refractory Ovarian Cancer
    Fallopian Tube Cancer
    Primary Peritoneal Cancer
    High-grade Serous Ovarian Cancer
    Endometrioid Ovarian Cancer
    Ovarian Clear Cell Carcinoma

NCT05281471

Genelux Corporation

11 October 2026

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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