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Comparing Cytarabine + Daunorubicin Therapy Versus Cytarabine + Daunorubicin + Venetoclax Versus Venetoclax + Azacitidine in Younger Patients With Intermediate Risk AML (A MyeloMATCH Treatment Trial)

Testing different drug combinations for younger patients with AML.

Recruiting
18-59 years
All
Phase 2
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study looks at different treatments for *Acute Myeloid Leukemia (AML)*, a type of blood cancer, in younger patients. It tests three combinations: **Cytarabine + Daunorubicin**, **Cytarabine + Daunorubicin + Venetoclax**, and **Venetoclax + Azacitidine**. *Cytarabine* and *Daunorubicin* help stop cancer cells from growing. *Venetoclax* and *Azacitidine* work differently to also block cancer cell growth. The goal is to see if adding Venetoclax helps more patients get rid of AML.

  • The study lasts several cycles, with follow-ups for 2+ years.
  • It requires regular visits for medication and tests.
  • Risks include possible side effects from the drugs used.

To join, participants must be aged 18-59, have specific types of AML, and meet health criteria. If you're interested, discuss with your doctor to see if this study is right for you. Eligible participants should be ready for frequent visits and follow-ups. This study aims to improve AML treatment for better patient outcomes.

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Study details
    Acute Myeloid Leukemia

NCT05554393

National Cancer Institute (NCI)

17 October 2026

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