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NBI-1065845-MDD3025: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

Join a study to test NBI-1065845 for depression treatment support.

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18 years and older
All
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)

Major Depressive Disorder (MDD) is a severe mental health condition causing persistent sadness and loss of interest. This study aims to test a new medicine, NBI-1065845, to see if it helps people with MDD feel better when used alongside their current antidepressants. A placebo is a harmless pill used to compare effects.

The study involves taking part in regular visits and following specific rules. Participants must have been taking their current antidepressants for at least 8 weeks and must have a moderate to severe level of depression. Their current depression treatment should not have worked well enough.

  • The study lasts several weeks, and participants need to keep taking their current antidepressants.
  • Regular visits to the research center are required for check-ups and tests.
  • Participants must not have other primary psychiatric disorders or be at risk of self-harm.

This study is for those who haven't fully responded to their current depression medication. It is important to discuss with a doctor to see if participating is right for you.

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Study details
    Major Depressive Disorder

NCT06911112

Neurocrine Biosciences

17 October 2026

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What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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