This study is testing a new drug called EVOLVE104 for people with advanced types of cancer such as bladder, lung, or skin cancer. The study aims to check if this drug is safe and works effectively for patients who have already tried other treatments or cannot take them. There are two stages in the study, and around 160 people will participate. In the first stage, the dose of the drug will be gradually increased to find the best amount, and in the second stage, more participants will be added to further examine the drug's effects.

Participants will receive the drug for about 10 months or until they can no longer continue due to reasons like the cancer getting worse or experiencing side effects. To join, participants need to have measurable cancer, good organ health, and agree to use birth control.

• The study lasts for about 10 months.
• Participants need to visit the clinic regularly for check-ups.
• Participants must meet specific health criteria to join.