This research aims to find out how well the drug Glofitamab, alone or with other drugs, works for treating a type of cancer called Richter's Transformation (RT). RT happens when Chronic Lymphocytic Leukemia (CLL) changes into a more aggressive form called diffuse large B-cell lymphoma (DLBCL). The study will test Glofitamab with other drugs like Polatuzumab Vedotin, Pirtobrutinib, and Atezolizumab, which are already used for other cancers.
- Participants will need to visit the clinic for about 9 months and have check-ups every 3-6 months for up to 10 years.
- About 70 people will be part of this study.
- Participants may undergo tests like blood and urine tests, scans, and heart check-ups.
If interested, make sure you meet the criteria and are willing to commit to the study's timeline. The drugs used in this study are not yet approved for RT but are approved for other uses. Discuss any risks and benefits with your doctor before joining.
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