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Phase III Study of Datopotamab Deruxtecan Versus Docetaxel in Previously Treated TROP2-positive Advanced or Metastatic Non-squamous NSCLC Without Actionable Genomic Alterations

Comparing two treatments for advanced non-squamous lung cancer.

Recruiting
18 years and older
All
Phase 3

This study is for people with advanced lung cancer called non-squamous non-small cell lung cancer (NSCLC) that doesn't have certain gene changes. It compares two treatments: datopotamab deruxtecan (Dato-DXd) and docetaxel, which are both drugs used for cancer treatment. The study aims to see which treatment works better and is safer. To be part of this study, participants must have already tried other cancer treatments and have specific lung cancer that tests positive for a protein called TROP2.

  • Participants will need to provide a tumor sample for testing.
  • The study involves multiple visits to the clinic for treatment and check-ups.
  • Check if you qualify based on your medical history and current health status.
Study details
    Non-small Cell Lung Cancer (NSCLC)

NCT07291037

AstraZeneca

17 October 2026

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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