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A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue

Investigating Ponsegromab in Adults with Metastatic Pancreatic Cancer and Cachexia

Recruiting
18 years and older
All
Phase 2/3

This study investigates pancreatic ductal adenocarcinoma. The purpose of this study is to evaluate treatments for adults with this condition who also experience significant weight loss and fatigue.

The study focuses on evaluating the safety, effectiveness, and tolerability of an investigational medication when used alongside chemotherapy. Researchers are interested in understanding how this combination works for people with this condition.

  • Who can participate: Adults diagnosed with metastatic pancreatic ductal adenocarcinoma and cachexia can participate if they have completed specific chemotherapy cycles and have an ECOG performance status of 1 or less.
  • Study details: Participants will receive either the investigational medication or a placebo along with chemotherapy. A placebo is an inactive substance that looks like the investigational medication but does not contain any medicine.
Study details
    Cachexia
    Metastatic Pancreatic Ductal Adenocarcinoma
    pancreatic cancer

NCT06989437

Pfizer

29 August 2026

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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