Major depressive disorder (MDD) is a serious mood problem that makes people feel sad for a long time and lose interest in things they used to enjoy. This study looks at how an investigational drug called Icalcaprant affects people with MDD who are going through a major depressive episode (MDE). An investigational drug is a medicine that is still being tested and is not yet approved for general use. Participants will be split into three groups; one group will receive a placebo, which is a pill with no active medicine, instead of Icalcaprant. About 195 adults will take part, and they will take a pill every day for 6 weeks. Afterward, there will be a 30-day safety check.
- Participants will have frequent checkups and tests at a hospital or clinic.
- They will answer questions about how they feel to see if the treatment is working.
- There might be more work involved than in regular care, including more visits and tests.
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