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Compassionate Use Study of Epi-ON Corneal Collagen Crosslinking Performed Using UVA Exposure on Eyes With Ectatic Corneal Diseases for Subjects With Down Syndrome

Study on new cornea treatment for Down Syndrome patients.

Recruiting
8 years and older
All
Phase 3
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study tests a treatment called *corneal crosslinking* (CXL) for eyes with ectatic corneal diseases, where the cornea (the clear front part of the eye) becomes thin and misshapen. CXL isn't approved by the FDA yet. It involves putting riboflavin (vitamin B2) drops on the eye and shining ultraviolet (UVA) light on it. This light is similar to sunlight and helps strengthen the cornea to prevent vision loss. Participants must be 8 years or older and have Down syndrome. The study seeks to find out if CXL can slow or stop these eye problems.

  • Participants must visit the clinic up to 7 times in 6 months.
  • Each visit includes several eye and vision tests.
  • Participants will receive the CXL treatment, which takes about 20 minutes.
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Study details
    Down Syndrome (DS)
    Keratoconus
    Pellucid Marginal Degeneration
    Forme Fruste Keratoconus (FFK)

NCT07135167

Woolfson Eye Institute

17 October 2026

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