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Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer

Exploring new treatment options for high-risk cervical cancer.

Recruiting
18 years and older
Female
Phase 3

This study is looking at treatments for high-risk cervical cancer, a type of cancer affecting the cervix, which is the lower part of the uterus. The study is comparing two treatment plans. One plan uses chemotherapy and a medicine called pembrolizumab before radiation, followed by more pembrolizumab. The other plan uses chemotherapy and radiation at the same time, followed by pembrolizumab. Pembrolizumab is a type of immunotherapy, which helps the immune system attack cancer cells.

Key Points:

  • **Study Length**: Treatment involves cycles over several weeks, with follow-ups for up to 5 years.
  • **Visits**: Regular hospital visits for treatment and scans are needed.
  • **Risks**: Possible side effects include fatigue, nausea, or serious reactions.

Before joining, consider the commitment needed for frequent hospital visits and the potential side effects. The study aims to find out if adding more treatments will help patients live longer without the cancer getting worse.

Study details
    Locally Advanced Cervical Adenocarcinoma
    Locally Advanced Cervical Adenosquamous Carcinoma
    Locally Advanced Cervical Squamous Cell Carcinoma
    Stage IIIA Cervical Cancer FIGO 2018
    Stage IIIB Cervical Cancer FIGO 2018
    Stage IIIC1 Cervical Cancer FIGO 2018
    Stage IIIC2 Cervical Cancer FIGO 2018
    Stage IVA Cervical Cancer FIGO 2018

NCT07061977

National Cancer Institute (NCI)

17 October 2026

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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