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AMG 410 Alone and in Combination With Other Agents in Participants With KRAS Altered Advanced or Metastatic Solid Tumors

Study on AMG 410 for advanced KRAS-altered tumors.

Recruiting
18 years and older
All
Phase 1
  • Simplified description (AI rewritten)
  • Technical description (Original)
Study Summary: This research is exploring a new medicine called AMG 410 for adults (18+) with advanced or metastatic solid tumors that have changes in a gene called KRAS. These tumors grow aggressively and may have spread to other parts of the body. The study aims to find the safest dose of AMG 410, either given alone or with other treatments, to see how well it works and how the body processes it. Key Points:
  • The study can last up to 3 years, with participants taking AMG 410 until their disease progresses or they experience unacceptable side effects.
  • Participants must have no other treatment options or have refused them, and they must be able to swallow the medication.
  • People with recent major surgeries, certain infections, or other health conditions might not qualify for this study.
Note: Before joining, participants should discuss potential risks and benefits with their healthcare provider to ensure it’s a suitable option for their condition.
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Study details
    KRAS Altered Advanced or Metastatic Solid Tumors

NCT07094113

Amgen

17 October 2026

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