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Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 3 Semaglutide

Exploring medication for alcohol use in HIV patients.

Recruiting
18-99 years
All
Phase 2

This study is exploring a new treatment option for people with both HIV and Alcohol Use Disorder (AUD). AUD is when someone can't control their alcohol use, affecting their daily life. The study uses a medication called semaglutide, which is typically used for other conditions, but here it's used "off-label" to see if it helps reduce drinking. Participants will also receive support from a pharmacist and take part in counseling to help them change their drinking habits.

The study lasts for 12 weeks. Participants need to bring their medicine bottles to study visits to check how well they're following the treatment. They'll also answer questions about their alcohol use and readiness to change. People interested must be 18 or older, diagnosed with HIV, and meet certain criteria for alcohol use problems. They can't be pregnant, planning to become pregnant, or have certain medical conditions.

  • The study will last for 12 weeks and involve several visits.
  • Participants will receive counseling and will need to bring medication bottles to visits.
  • Participants must be over 18, have HIV, and meet specific alcohol use criteria.
Study details
    Alcohol Use Disorder (AUD)
    HIV

NCT07040592

Yale University

17 October 2026

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