Effect of Product Characteristics on the Abuse Liability of Nicotine Pouches This study explores how nicotine levels and pH (a measure of acidity) in nicotine pouches (NPs) affect their taste, attractiveness, and potential for misuse among young adult users. NPs are small, tobacco-free pouches that release nicotine in the mouth, which can quickly raise nicotine levels in the blood. This can lead to potential health issues like oral toxicity and heart problems, and increase the risk of addiction. The study is crucial because nicotine pouches are becoming more popular due to their discreet packaging and claims of being "tobacco-free." The FDA is considering stricter regulations on products like NPs due to their appeal to youth, similar to past actions on menthol cigarettes. By understanding how nicotine and pH interact, this study aims to inform regulatory actions to make these products less appealing and reduce misuse.

• The study targets current nicotine pouch users aged 18-24.
• Participants should not plan to quit nicotine use soon.
• Those with heart issues or are pregnant are not eligible.

Participating in this study could help shape future regulations to make nicotine products safer.