**This study** is looking at a medicine called **LB-102** to see if it helps adults with **Bipolar 1 Disorder** who are going through a major depressive episode (MDE). **Bipolar 1 Disorder** is a mental health condition that causes extreme mood swings. **MDE** is when someone feels really sad or depressed for a long time. In this **Phase II study**, which is like the second big test for a new treatment, people who join will take either the medicine **LB-102** or a placebo (a pill that looks the same but has no medicine). The study is **double-blind**, meaning neither the doctors nor the patients know who is getting the real medicine, making it fair. The treatment lasts for **6 weeks**. **Key Points:** - **Treatment Duration:** 6 weeks of daily medicine or placebo. - **Participation:** Must have Bipolar 1 Disorder and currently experiencing a major depressive episode. - **Compensation:** Participants could be compensated for their time and travel. People considering joining should talk to their doctor to see if they qualify and to understand any risks or benefits.