This study is testing new treatments for advanced head and neck cancer. Sometimes, cancer can come back or spread after it seemed to get better. This study looks at adding chemotherapy or chemo-immunotherapy to the usual surgery to see if it helps more. Chemotherapy uses drugs like carboplatin and paclitaxel to kill cancer cells or stop them from growing. Chemo-immunotherapy adds a drug called cemiplimab that helps the body's immune system fight cancer. Salvage surgery is a kind of surgery done when cancer comes back. After surgery, patients also get radiation therapy, which uses high-energy x-rays to kill cancer cells.
- Study Length: Patients will be followed up for several years after treatment.
- Visits: Patients need to visit for treatments and scans during the study.
- Risks: There may be side effects from the treatments, like low blood counts or nausea.
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