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Using Biomarker Tests to Select and Test New, Personalized Treatments for Extensive Stage Small Cell Lung Cancer, PRISM Study

Join the PRISM Study: Personalized treatments for extensive stage small cell lung cancer.

Recruiting
18 years and older
All
Phase 2
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is designed to find the best personalized treatments for patients with extensive stage small cell lung cancer (ES-SCLC) using biomarker tests. Biomarkers are features in cancer cells that help doctors decide the best treatment. Patients are grouped based on their cancer type and specific biomarker results. The study tests different drugs such as durvalumab, saruparib, ceralasertib, and monalizumab for maintenance treatment, which is given after initial treatment to keep cancer under control. Durvalumab and monalizumab are immunotherapy drugs that help the immune system fight cancer. Saruparib is a PARP inhibitor that stops cancer cells from fixing their DNA, and ceralasertib blocks enzymes needed for tumor growth.

  • The study lasts for several years, with follow-ups up to 3 years after treatment.
  • Participants need to undergo regular scans and tissue sample collections.
  • No previous exposure to certain cancer drugs is allowed for participation.
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Study details
    Extensive Stage Lung Small Cell Carcinoma
    Lung Small Cell Carcinoma
    A Subtype
    Lung Small Cell Carcinoma
    I Subtype
    Lung Small Cell Carcinoma
    N Subtype
    Lung Small Cell Carcinoma
    P Subtype

NCT06769126

SWOG Cancer Research Network

11 October 2026

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