This study looks at the safety of using tiny particles called *exosomes* from stem cells found in the umbilical cord to help treat Parkinson's Disease. *Exosomes* are like tiny packages that carry important messages to cells. These exosomes will be given through the nose, known as *intranasal installation*. The study will check how safe it is and if it helps with Parkinson's symptoms.
Participants will get two doses, each 4 CCs, of these exosomes in the nose over two days. They will be checked for safety and how well it works before treatment and at 1, 6, 12, 24, 36, and 48 months after treatment.
- Participants must have Parkinson's Disease and agree to sign a consent form.
- Those with active infections, cancer, or certain other health problems cannot join.
- Women who are pregnant or not using contraception cannot participate.
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