This study focuses on understanding depression in people with Parkinson's disease, a brain disorder that affects movement. The study will use special imaging techniques, PET and MRI scans, to look at the brains of people with Parkinson's who are feeling depressed. Participants, aged 40-80, will be compared to those without depression, those with just depression (no Parkinson's), and healthy individuals. The study involves two visits, lasting 7 hours total, for scans and assessments.
Some participants may choose to receive a dose of ketamine, a medication often used for depression, to see if it affects brain changes related to depression. This will require an extra visit for a post-treatment scan.
- Study duration is approximately 7 hours, including all visits.
- Includes PET and MRI scans, and an optional ketamine treatment.
- Participants will be divided into four groups based on their health condition.
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