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Adaptive vs. Continuous Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease

Comparing two types of brain stimulation for Parkinson's Disease symptoms.

Recruiting
18 years and older
All
Phase N/A

The CLOSE-PD study is researching two types of deep brain stimulation treatments for people with Parkinson's disease, a brain disorder affecting movement. Deep Brain Stimulation (DBS) involves placing electrodes in the brain to help control movement symptoms. Adaptive DBS (aDBS) adjusts the stimulation based on brain signals, while Continuous DBS (cDBS) provides constant stimulation.

The study will compare whether aDBS provides longer periods of good movement control without troublesome movements, called dyskinesia, compared to cDBS over six months. Participants will be randomly assigned to either aDBS or cDBS two weeks after their initial setup session. They will have follow-up visits at three and six months and keep a diary about their symptoms at various points.

  • Study lasts for six months with follow-ups at three and six months.
  • Participants are randomly assigned to either aDBS or cDBS.
  • Participants must have prior DBS electrode implants.

Only adults diagnosed with Parkinson's, who speak Dutch, and meet other criteria can join. Those with memory issues, unable to tell movement changes, or involved in other similar studies cannot participate.

Study details
    Deep Brain Stimulation
    Parkinson Disease

NCT06909045

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

17 April 2026

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