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Pharmacologically Modulating the Noradrenergic Arousal System to Reduce Freezing of Gait in Parkinson's Disease: a Multi-centre and Multi-modal Approach

Testing a new method to help Parkinson's patients with walking issues.

Recruiting
18 years and older
All
Phase 3

This study is for people with **Parkinson's disease** (a brain disorder causing shaking and movement problems) who have **freezing of gait** (where you suddenly stop walking and can't move your feet). The aim is to check if a medicine called **atomoxetine** can help. Atomoxetine is compared to a **placebo** (a fake treatment) to see if it reduces freezing of gait. Participants will visit a study center for tests, take medicine or placebo, do walking assessments, have brain scans (MRI), and answer questions about anxiety, stress, and their life quality.

  • **Time Commitment**: The study requires visits to a research center for tests and assessments.
  • **Participation Requirements**: You must be 18 or older, have Parkinson's with daily freezing of gait, and be on stable Parkinson's treatment.
  • **Potential Risks**: Some medical conditions or medicines might prevent participation, so eligibility will be checked.
Study details
    Parkinson's Disease (PD)
    Freezing of Gait
    Freezing of Gait Symptoms in Parkinson Disease

NCT07316296

Radboud University Medical Center

17 April 2026

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What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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