Study Purpose: This study is exploring if certain enzymes, called cyclooxygenase (COX-1 and COX-2), are higher in the brains of people with diseases like Alzheimer's. These enzymes are related to brain inflammation.

Study Details: Participants will have several medical assessments, including a magnetic resonance imaging (MRI) scan and two positron emission tomography (PET) scans. The MRI is a large tube that uses magnets to take pictures of the brain, while the PET scan uses a machine shaped like a donut to create brain images after injecting a special dye. The study will last from 1 week to 4 months, depending on scheduling needs.

• Participants need to be 18 or older and in good health, even if they have a neurodegenerative disorder.
• There will be 2-5 study visits.
• Participants will be screened to ensure they do not have conditions that could affect the study results, like recent NSAID use or certain medical devices.

This study helps researchers understand brain inflammation better, which could lead to improved treatments for neurodegenerative diseases.