This study looks at early signs of Parkinson's Disease (PD) using a special scan called [18F] AV-133 PET imaging. It's a *longitudinal study*, meaning it follows people over time, for up to 24 months. *Prodromal PD* means participants show early signs of PD but don't have full symptoms yet. In this study, 100 participants across 10 sites will have scans and health checks at the start, and then again at 12 and 24 months. This helps researchers understand PD better and find ways to slow it down.

• The study lasts for 2 years with 3 major assessments: at the start, after 1 year, and after 2 years.
• Participants must be 18 or older and able to give consent.
• Women must ensure they're not pregnant and use effective birth control.

This study does not allow participants on certain medications or with certain health conditions. Knowing these details can help decide if joining is right for you.