This study is for people with Parkinson's disease (PD), a disorder that affects movement and can cause stiffness or tremors. It's testing a special exercise program done at home with a virtual trainer. This program combines endurance exercises (like running or cycling) with resistance exercises (like weight lifting) to see if it helps improve thinking skills and find biological changes, called biomarkers, in blood, saliva, or spinal fluid. The study lasts for 26 weeks (about 6 months), and you may be asked to do exercises with a trainer or just wait and do no exercise. **Key Points to Consider:** - **Duration:** The study lasts 26 weeks. - **Visits Required:** Participants will have assessments at the start and end of the study. - **Eligibility:** Participants must have Parkinson's, be 40-80 years old, and have stable medication use if on PD medications. This study is important because it could help people with PD improve their quality of life and teach us more about how exercise affects the brain.