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Uncovering a Novel Therapeutic Target to Reduce Dementia Risk in Parkinson's Disease

Exploring new ways to lower dementia risk in Parkinson's.

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Phase 2

This study is exploring how a low dose of an anti-epileptic drug called **levetiracetam** can help with memory issues in people with **Parkinson's Disease (PD)**. Parkinson's Disease is a condition that affects the brain and movement. **Neuroimaging techniques** (special brain scans) will show how the drug affects certain parts of the brain, like the **hippocampal subfields**, which are involved in memory. The study compares brain activity in PD patients with and without memory problems and healthy older adults. This could help find out if certain brain activities can predict memory issues in PD.

Key Points:

  • The study includes people with PD who have mild memory problems and those without, as well as healthy volunteers.
  • Participants must be able to have an MRI (a type of brain scan) and not have conditions like dementia or severe kidney issues.
  • The study aims to help guide future treatments targeting specific brain areas to improve memory in PD patients.
Study details
    Parkinson Disease
    Mild Cognitive Impairment
    Memory Impairment

NCT04643327

The University of Queensland

17 April 2026

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What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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