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Evaluation of Neurocognitive Changes in Parkinson's Disease After Low Frequency Burst Stimulation

Studying brain effects of low-frequency stimulation in Parkinson's patients.

Recruiting
18 years and older
All
Phase N/A

This study is for people with Parkinson's Disease who already have a deep brain stimulator. It looks at how changing the brain stimulation might help with thinking skills, called *cognition*. This study uses a special kind of brain stimulation called *theta burst stimulation*, which is compared to regular stimulation. Participants will take tests to see how well they think and move. The study lasts for one year, and involves changes to the stimulation settings at different times. Participants will have brain scans called fMRI (functional magnetic resonance imaging) at specific times during the study to check brain activity. You must be over 18 and have stable medication to join. People with epilepsy, dementia, or major substance abuse cannot join.

  • The study is one year long with different phases and testing.
  • Participants will have brain scans and take thinking and movement tests.
  • People with certain medical histories can't participate.
Study details
    Parkinson Disease

NCT05307055

University of Southern California

17 April 2026

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What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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