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Elucidating the Role of Cholinergic Degeneration in Cognitive Fluctuations in Lewy Body Dementia

Studying brain changes in Lewy Body Dementia's memory issues.

Recruiting
50-89 years
All
Phase 4

This study explores how brain changes affect thinking in people with Lewy Body Dementia (LBD) and Parkinson's Disease Dementia (PDD). **Lewy Body Dementia** is a condition where abnormal protein deposits, called Lewy bodies, build up in the brain, affecting memory and thinking. **Cognitive Fluctuations (CF)** refer to changes in attention and thinking ability. The study uses brain scans and a test called **EEG** (Electroencephalogram) to measure brain waves. Participants include those with LBD or PDD, some of whom will try a medication called **cholinesterase inhibitor** (helps memory) for 8 weeks. The study lasts for 2 years, with yearly follow-ups to see how thinking changes over time.

  • The research lasts 2 years, with annual follow-ups.
  • Participants in the medication group will try the treatment for 8 weeks.
  • Participants must be 50 to 89 years old and able to follow study procedures.
Study details
    Dementia With Lewy Bodies
    Parkinson Disease Dementia
    Healthy Controls

NCT07284290

Virginia Commonwealth University

17 April 2026

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