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Exploring the Possible Beneficial Impact of Non-invasive and Invasive Neuromodulation on Freezing of Gait in Parkinson's Disease During Different Ambulatory Complexities: An Electrophysiological and fMRI Study

Studying new treatments for walking issues in Parkinson's disease.

Recruiting
20-90 years
All
Phase N/A
  • Simplified description (AI rewritten)
  • Technical description (Original)

Parkinson's disease (PD) is a brain disorder that can cause freezing of gait (FOG), where a person feels stuck and can't walk properly. This study aims to find ways to understand and help with FOG. Researchers will use advanced technology like **artificial intelligence (AI)** to identify and measure FOG episodes. Special video equipment and foot pressure sensors will collect data during walking tests. They will also study brain activity using **electrophysiology** (a method to record electrical signals in the brain) and **fMRI** (a brain imaging technique) to learn more about FOG's causes. Non-invasive treatments like **transcranial direct current stimulation (tDCS)** and **magnetic resonance-guided focused ultrasound (MRgFUS)**, as well as Deep Brain Stimulation (DBS), will be tested for their effects on FOG in PD patients.

  • This study lasts for 3 years and involves multiple tests and treatments.
  • Participants need to have Parkinson's disease and be between 20 to 90 years old.
  • Patients will undergo various treatments and brain imaging before and after interventions.
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Study details
    Transcranial Direct Current Stimulation

NCT06505460

China Medical University Hospital

17 April 2026

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